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Hilton Jacksonville at Mayo Clinic Debuts on Mayo Clinic Campus

A room with bed, couch, tv, and large windows.

Hilton Jacksonville at Mayo Clinic

JACKSONVILLE, Fla. — Hilton Jacksonville at Mayo Clinic is officially open and welcomes guests for the first time today, marking the first full-service hotel opening in the Jacksonville market in nearly two decades. Since construction first began in 2023, the eight-story, 252-room property has been one of Northeast Florida’s most anticipated hotel openings. Located on the Mayo Clinic campus, the property combines Hilton’s world-class hospitality with the easygoing spirit of coastal Florida. The hotel is also one of the newest Hilton Hotels & Resorts properties to debut the brand’s refreshed identity, a modernized expression of Hilton, reflected through enhanced design and reimagined service touchpoints.

The exterior of the Hilton Jacksonville at Mayo Clinic
Hilton Jacksonville at Mayo Clinic - Entrance Exterior

“Opening Hilton Jacksonville at Mayo Clinic is deeply meaningful for our team and allows us to demonstrate to every guest that it truly does matter where you stay,” said Jayson Zimmer, general manager, Hilton Jacksonville at Mayo Clinic. “We are creating a welcoming haven for guests at pivotal moments in their lives. Whether guests are here to support a loved one, celebrate a milestone, or simply enjoy the beauty of Northeast Florida, our goal is to provide genuine care, comfort, and memorable experiences that reflect both Hilton’s legacy and the spirit of this community.”

A lobby with various clusters of chairs
Hilton Jacksonville at Mayo Clinic - Lobby

Hilton Jacksonville at Mayo Clinic is the first Hilton Hotels & Resorts property in the city and located just minutes from Jacksonville’s sun-soaked beaches, championship golf courses, and vibrant cultural attractions. Spanning more than 184,000 square feet, the hotel is designed to welcome leisure travelers, corporate guests, wellness seekers, and families. The property is managed by Concord Hospitality, an award-winning hotel management and development company recognized for its high-touch service and longstanding partnerships with leading hospitality brands.

A room with bed and couch
Hilton Jacksonville at Mayo Clinic - Guest Room

"This hotel will bridge the Mayo Clinic's care and advanced medical expertise with the world-class service and hospitality of Hilton. We are so pleased to have been a part of this incredible collaboration, which took much time and patience, and we are grateful to our partners at Mayo Clinic, Hilton, and Concord Hospitality for their tireless support in bringing it to fruition,” said Paul Novak, partner, Whitman Peterson. “We look forward to inviting more people to Jacksonville and to the Mayo Clinic's campus in the coming years."

Among its many guest offerings, the hotel’s signature restaurant, Coastal Kitchen, blends a light-filled coastal design with a wellness-inspired menu crafted by Executive Chef Andrew Kallsnick. The restaurant celebrates both nourishment and indulgence with fresh seafood, vibrant seasonal ingredients, and global influences. From Mayport Shrimp Rolls and Achiote Mahi Tacos to Florida Key Lime Pie, Coastal Kitchen’s menu offers a refined yet approachable dining experience that reflects the spirit of Northeast Florida and the Atlantic coastline.

Guests can expect a full-service experience with standout amenities, including:

  • 252 guest rooms, featuring 21 spacious suites, water views, nature views, and more to accommodate every type of traveler
  • More than 21,000 square feet of event space to host iconic gatherings, including a grand pillarless ballroom, junior ballroom, boardrooms, and a spectacular 5,000 square feet outdoor event lawn overlooking serene water
  • Resort-style outdoor heated, zero-entry pool and a covered outdoor terrace surrounded by lush landscaping
  • 24-hour expansive fitness center
  • A sleek coffee shop in the lobby, offering smoothies, locally sourced coffee, and grab-and-go breakfast and lunch items
  • In-room dining service, offering guests comfort and quality any time of day

Surrounded by trees and ponds, the hotel’s design by DLR Group reflects its environment. Warm textures, lively glass, and clean modern lines capture the area’s natural beauty while delivering a refined, peaceful guest experience. As an added nod to its community, the main guest room tower conveys a sense of peaceful strength, anchored on a stone plinth and accented with bright architectural frames that rise with confidence.

Hilton Jacksonville at Mayo Clinic is located at 4745 Transformation Way, Jacksonville, FL 32224. For more information, visit hilton.com. For reservations, call +1 904 929 9000, or visit hilton.com/en/hotels/jaxmohh-hilton-jacksonville-at-mayo-clinic/.

Media Contact

Carli BrinkmanCARLI PRCB@CarliPR.com
Erica BadgleyCARLI PRErica@CarliPR.com
Liza AhmadHiltonLiza.Ahmad@hilton.com

About Hilton

Hilton (NYSE: HLT) is a leading global hospitality company with a portfolio of 24 world-class brands comprising more than 9,000 properties and over 1.3 million rooms, in 139 countries and territories. Dedicated to fulfilling its founding vision to fill the earth with the light and warmth of hospitality, Hilton has welcomed over 3 billion guests in its more than 100-year history, was named the No. 1 World’s Best Workplace by Great Place to Work and Fortune and has been recognized as a global leader on the Dow Jones Sustainability Indices. Hilton has introduced industry-leading technology enhancements to improve the guest experience, including Digital Key Share, automated complimentary room upgrades and the ability to book confirmed connecting rooms. Through the award-winning guest loyalty program Hilton Honors, the more than 226 million Hilton Honors members who book directly with Hilton can earn Points for hotel stays and experiences money can't buy. With the free Hilton Honors app, guests can book their stay, select their room, check in, unlock their door with a Digital Key and check out, all from their smartphone. Visit stories.hilton.com for more information, and connect with Hilton on FacebookXLinkedInInstagram and YouTube.


About Hilton Hotels & Resorts

For over a century, Hilton Hotels & Resorts has set the benchmark for hospitality around the globe, connecting people, cultures and communities. Offering striking design and vibrant communal spaces—from buzzing lobbies to lively bars, best-in-class restaurants, and iconic event venues— Hilton Hotels & Resorts is the place to see and be seen in the world’s most sought-after destinations. With more than 600 hotels across six continents, Hilton Hotels & Resorts is where the world comes together, and travelers are masterfully hosted with expertise and care.  Experience a legendary stay at Hilton Hotels & Resorts by booking at hiltonhotels.com or through the industry leading Hilton Honors app. Hilton Honors members who book directly through preferred Hilton channels have access to instant benefits. Learn more about Hilton Hotels & Resorts at stories.hilton.com/hhr, and follow the brand on Facebook, X and Instagram.


About Concord Hospitality

Concord Hospitality is an award-winning hotel development and management company that has grown over the past three decades to become the preferred partner of leading hotel brands such as Hilton, Marriott, and Hyatt. Concord Hospitality boasts a stellar reputation known for combining the experience of a big company with the high-touch service of an independent operation to every partner property. The company specializes in developing and managing full-service and select-service hotels across North America. As part of the company’s continued growth, it recently launched Opus Collection by Concord, a lifestyle hotel management division for full-service properties. With the brightest talent, the most innovative processes, and a commitment to giving back to the communities where associates live and work, Concord Hospitality is committed to being a great place to work for all. Learn more at concordhotels.com.